任雪峰 教授

博士生导师，精准基因环境研究创新实验室负责人。在美国华盛顿大学和Hutchinson 癌症研究中心获得理学博士学位。曾在美国加州大学伯克利分校进行博士后研究，在美国纽约州立大学布法罗分校公共卫生学院和医学院担任终身教授。迄今为止，主持和承担包括美国NIH/NIEHS，NIH/NCI，纽约州立大学研究项目，中国国家自然基金研究项目等多项公共卫生领域及基础和转化医学项目。致力于化学致癌物和重金属毒性机制研究，及相关治疗预防药物的研发，取得多项原创性的成果。在国际专业领域杂志，包括Environmental Health Perspectives，Environment International等发表50多篇SCI论文。获批多项国际国内发明专利，相关科研成果顺利进入临床转化，其中合作研发的I类化学新药GMDTC已获批开展临床实验，拥有自主知识产权的动脉粥样硬化性心脑血管疾病预防治疗天然药物正式进入临床开发。曾担任美国美国国立环境研究院，基础医学研究院项目评审专家组成员，欧盟及新加坡政府研究项目特聘评审专家，并在相关国际专业杂志和专业学会担任编委或学术兼职。曾获得Society of Toxicology (SOT) “Best Postdoctoral Paper of the Year Award”和“Young Investigator Award”，SUNY at Buffalo “Distinguished Research Award”。

研究方向：化学致癌物和重金属病理机制及防治研究

联系方式：

地址：杭州市滨江区滨文路548号

电话：0571-86603117

邮箱：xfren@zcmu.edu.cn

代表性论文：

1. Li M, Feng J, Cheng Y, Dong N, Tian X, Liu P, Zhao Y, Qiu Y, Tian F, Lyu Y, Zhao Q, Wei C, Wang M, Yuan J, Ying X, Ren X, Yan X. Arsenic-fluoride co-exposure induced endoplasmic reticulum stress resulting in apoptosis in rat heart and H9c2 cells. Chemosphere. 2022 Feb;288(Pt 2):132518. doi: 10.1016/j.chemosphere.2021.132518. PMID: 34637859

2. VanEtten SL, Bonner MR, Ren X, Birnbaum LS, Kostyniak PJ, Wang J, Olson JR. Effect of exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) on mitochondrial DNA (mtDNA) copy number in rats. Toxicology. 2021 Apr 30;454:152744. doi: 10.1016/j.tox.2021.152744. PMID: 33677009

3. Yan X, Chen X, Tian X, Qiu Y, Wang J, Yu G, Dong N, Feng J, Xie J, Nalesnik M, Niu R, Xiao B, Song G, Quinones S, Ren X. Co-exposure to inorganic arsenic and fluoride prominently disrupts gut microbiota equilibrium and induces adverse cardiovascular effects in offspring rats. Sci Total Environ. 2021 May 1;767:144924. doi: 10.1016/j.scitotenv.2020.144924. PMID: 33636766

4. Sulaiman R, Wang M, Ren X. Exposure to Aluminum, Cadmium, and Mercury and Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis. Chem Res Toxicol. 2020 Nov 16;33(11):2699-2718. doi: 10.1021/acs.chemrestox.0c00167. PMID: 32990432

5. VanEtten SL, Bonner MR, Ren X, Birnbaum LS, Kostyniak PJ, Wang J, Olson JR. Telomeres as targets for the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) in rats. Toxicol Appl Pharmacol. 2020 Dec 1;408:115264. doi: 10.1016/j.taap.2020.115264. PMID: 33022284

6. Qiu Y, Chen X, Yan X, Wang J, Yu G, Ma W, Xiao B, Quinones S, Tian X, Ren X. Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride. Environ Int. 2020 Jul;140:105763. doi: 10.1016/j.envint.2020.105763. PMID: 32371304

7. Tian X, Xie J, Chen X, Dong N, Feng J, Gao Y, Tian F, Zhang W, Qiu Y, Niu R, Ren X, Yan X. Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring. Arch Toxicol. 2020 Mar;94(3):749-760. doi: 10.1007/s00204-019-02651-y.

8. Ge Y, Zheng N, Chen X, Zhu J, Sun W, Olson JR, Aga DS, Hu W, Tang X, Ren X. GMDTC Chelating Agent Attenuates Cisplatin-Induced Systemic Toxicity without Affecting Antitumor Efficacy. Chem Res Toxicol. 2019 32(8):1572-1582. doi: 10.1021/acs.chemrestox.9b00097. Epub 2019 Jul 9.

9. Liu Y, Chen X, Gong Z, Zhang H, Fei F, Tang X, Wang J, Xu P, Zarbl H, Ren X. Fry Is Required for Mammary Gland Development During Pregnant Periods and Affects the Morphology and Growth of Breast Cancer Cells. Front Oncol. 2019 9:1279. doi: 10.3389/fonc.2019.01279.

10. Wang M, Hossain F, Sulaiman R, Ren X. Environmental Inorganic Arsenic and Lead Exposures and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. Chem. Res. Toxicol2019 Oct 21;32(10):1904-1919. doi: 10.1021/acs.chemrestox.9b00134. PMID: 31549506

11. Zhen N, Ge Y, Tang X, Chen X, Sun W, Ren X. The Effect of GMDTC in Reducing Cisplatin-Induced Toxicities and Increasing Chemotherapeutic Effects. Cancer Chemotherapy and Pharmacology. Chem Res Toxicol. 2019 Aug 19;32(8):1572-1582. doi: 10.1021/acs.chemrestox.9b00097. PMID: 31240907

12. Tian X, Feng J, Dong N, Liu Y, Wei C, Li B, Ma Y, Xie J, Qiu Y, Song G, Ren X, Yan X. Subchronic exposure to arsenite and fluoride from gestation to puberty induces oxidative stress and disrupts ultrastructure in the kidneys of rat offspring. Science of The Total Environment, 2019, 686:1229-1237. https://doi.org/10.1016/j.scitotenv.2019.04.409

13. Gong Z, Wang J, Wang D, Buas MF, Ren X, Freudenheim JL, Belinsky SA, Liu S, Ambrosone CB, Higgins MJ. Differences in microRNA expression in breast cancer between women of African and European ancestry. Carcinogenesis. 2019 Mar 12;40(1):61-69. doi: 10.1093/carcin/bgy134.

14. Guo X, Chen X, Wang J, Liu Z, Gaile D, Wu H, Yu G, Mao G, Yang Z, Di Z, Guo X, Cao L, Chang P, Kang B, Chen J, Gao W, Ren X. Multi-generational Impacts of Arsenic Exposure on Genome-wide DNA Methylation and the Implications for Arsenic-induced Skin Lesions. Environ Int. 2018 Oct;119:250-263. doi: 10.1016/j.envint.2018.06.024

15. Ge Y, Zhu J, Wang X, Zheng N, Tu C, Qu J, Ren X. Mapping dynamic histone modification patterns during arsenic-induced malignant transformation of human bladder cells. Toxicol Appl Pharmacol. 2018 Sep 15;355:164-173. doi: 10.1016/j.taap.2018.06.029. PMID: 29966674

16. Callahan CL, Pavuk M, Birnbaum LS, Ren X, Olson JR, Bonner MR. Serum polychlorinated biphenyls and leukocyte telomere length in a highly-exposed population: The Anniston Community Health Survey. Environ Int. 2017; 108:212-220.

17. Zhu J, Wang J, Chen X, Tsompana M, Gaile D, Buck M, Ren X. A Time-Series Analysis of Altered Histone H3 Acetylation and Gene Expression during the Course of MMAIII-Induced Malignant Transformation of Urinary Bladder Cells. Carcinogenesis. 2017 Apr 1;38(4):378-390. doi: 10.1093/carcin/bgx011.

18. Chen X, Guo X, He P, Nie J, Yan X, Zhu J, Zhang L, Mao G, Wu H, Liu Z, Aga D, Xu P, Smith M, Ren X. Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China. Toxicol Sci. 2017 Jan;155(1):124-134. doi: 10.1093/toxsci/kfw181.

19. Wang Y, Hollis-Hansen K, Ren X, Qiu Y, Qu W. Do environmental pollutants increase obesity risk in humans? Obes Rev. 2016 Dec;17(12):1179-1197. doi: 10.1111/obr.12463.

20. Tang X, Zhu J, Zhong Z, Luo M, Li G, Gong Z, Zhang C, Fei F, Ruan X, Zhou J, Liu G, Li G, Olson J, Ren X. Mobilization and removing of cadmium from kidney by GMDTC utilizing renal glucose reabsorption pathway. Toxicol Appl Pharmacol. 2016 Aug 15;305:143-52. doi: 10.1016/j.taap.2016.06.001.

21. Zhang H, Ge Y, He P, Chen X, Carina A, Qiu Y, Aga D, Ren X . Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation. Toxicol Sci, 2015, 146(2):354-62.

22. Ren X, Gaile D, Gong Z, Qiu W, Ge Y, Zhang C, Huang C, Yan H, Olson JR., Kavanagh TJ., Wu H. Arsenic responsive microRNAs in vivo and their potential involvement in arsenic-induced oxidative stress. Toxicol Appl Pharmacol, 2015; 283(3):198-209. doi: 10.1016/j.taap.2015.01.014.

23. Ren X, Graham JC, Jing L, Mikheev AM, Gao Y, Lew JP, Xie H, Kim AS, Shang X, Friedman C, Vail G, Fang MZ, Bromberg Y, Zarbl H. Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene. PLoS One. 2013. 8(9):e70930. doi: 10.1371/journal.pone.0070930. eCollection 2013.

24. Ge Y, Gong Z, Olson JR, Xu P, Buck MJ, Ren X. Inhibition of monomethylarsonous acid (MMA(III))-induced cell malignant transformation through restoring dysregulated histone acetylation. Toxicology. 2013. 312:30-5. doi: 10.1016/j.tox.2013.07.011.

25. Tang X, Li N, Kang L, Dubois AM, Gong Z, Wu B, Lai G, Yang A, Ruan X, Gao H, Zhu G, Ge Y, Zhang J, Lin Z, Olson JR, Ren X. Chronic low level trimethyltin exposure and the risk of developing nephrolithiasis. Occup Environ Med. 2013. 70(8):561-7. doi: 10.1136/oemed-2012-101261.

26. Ren X, Ji Z, Yuh J, Tang M, Bersonda J, Smith MT and Zhang L. The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines. Arch Tox. 2012. 87(1):189-196. PMID: 22872141.

27. Ren X, McHale CM, Skibola CF, Smith AH, Smith MT and Zhang L. An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ Health Perspect, 2011. 119(1):11-19. PMID: 20682481. PMCID: PMC3018488.

28. Ren X, Lim S, Ji Z, Yuh J, Peng V, Smith MT and Zhang L. Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One, 2011. 6(1):e14546. doi:10.1371/journal.pone.0014546. PMID: 21267443. PMCID: PMC3022623.

29. Ren X, Aleshin M, Jo WJ, Dills R, Kalman DA, Vulpe CD, Smith MT and Zhang L. Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity. Environ Health Perspect, 2011. 119(6):771-777. PMID: 21193388. PMCID: PMC3114810.

30. Chu F, Ren X, Chasse A, Hickman T, Zhang L, Yuh J, Smith MT and Burlingame AL. Quantitative mass spectrometry reveals the epigenome as a target of arsenic. Chem Biol Interact, 2011. 192(1-2):113-117. PMID: 21075096.

31. Zhang L, McHale CM, Rothman N, Li G, Ji Z, Vermeulen R, Hubbard AE, Ren X, Shen M, Rappaport SM, North M, Skibola CF, Yin S, Vulpe C, Chanock SJ, Smith MT and Lan Q. Systems biology of human benzene exposure. Chem Biol Interact, 2010. 184(1-2):86-93. PMID: 20026094. PMCID: PMC2846187.

32. Ji Z, Zhang L, Peng V, Ren X, McHale CM and Smith MT. A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide. Leukemia, 2010. 24(5):986-991. PMID: 20339439.

33. Ren X, Lim S, Smith MT and Zhang L. Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone. Toxicol Sci, 2009. 107(2):367-375. PMID: 19064679.

34. Ren X, Jo WJ, Chu F, Aleshin M, Wintz H, Burlingame A, Smith MT, Vulpe CD and Zhang L. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol Appl Pharmacol, 2009. 241(3):294-302. PMID: 19732783. PMCID: PMC2784148.

35. Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, Li G, Vulpe C, Lim S, Ren X, Rappaport SM, Berndt SI, Yeager M, Yuenger J, Hayes RB, Linet M, Yin S, Chanock S, Smith MT, Rothman N. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis. 2009. 30(1):50-8. doi: 10.1093/carcin/bgn249.

36. Ren X, Zhang X, Kim AS, Mikheev AM, Fang M, Sullivan RC, Bumgarner RE, Zarbl H.. Comparative genomics of susceptibility to mammary carcinogenesis among inbred rat strains: role of reduced prolactin signaling in resistance of the Copenhagen strain. Carcinogenesis. 2008. 29(1):177-85.